The first day I would build
Give the city one clear route before adding extras.
- Start with Casco Viejo and Miraflores Locks while energy is high.
- Use Cinta Costera as the natural reset instead of crossing town too early.
the easier plan is Miraflores Locks as its own block, Casco Viejo later, Cinta Costera or Panama Viejo when timing stays clean. That keeps the day readable instead of turning every good name into a separate detour.
I would rather leave one place for tomorrow than drag a tired route through Metropolitan Natural Park just because it looked close on a map.