The first day I would build
Give the city one clear route before adding extras.
- Start with Costanera and Palacio de los Lopez while energy is high.
- Use Loma San Jeronimo as the natural reset instead of crossing town too early.
the easier plan is old center and Costanera first, Villa Morra or Loma San Jeronimo later. That keeps the day readable instead of turning every good name into a separate detour.
I would rather leave one place for tomorrow than drag a tired route through Villa Morra just because it looked close on a map.